Research Area:  Machine Learning
Recently, using artificial intelligence (AI) in drug discovery has received much attention since it significantly shortens the time and cost of developing new drugs. Deep learning (DL)-based approaches are increasingly being used in all stages of drug development as DL technology advances, and drug-related data grows. Therefore, this paper presents a systematic Literature review (SLR) that integrates the recent DL technologies and applications in drug discovery Including, drug–target interactions (DTIs), drug–drug similarity interactions (DDIs), drug sensitivity and responsiveness, and drug-side effect predictions. We present a review of more than 300 articles between 2000 and 2022. The benchmark data sets, the databases, and the evaluation measures are also presented. In addition, this paper provides an overview of how explainable AI (XAI) supports drug discovery problems. The drug dosing optimization and success stories are discussed as well. Finally, digital twining (DT) and open issues are suggested as future research challenges for drug discovery problems. Challenges to be addressed, future research directions are identified, and an extensive bibliography is also included.
Keywords:  
Drug discovery
Artificial intelligence
Deep learning
Drug–target interactions
Drug–drug similarity
Drug side-effects
Drug sensitivity and response
Drug dosing optimization
Explainable artificial intelligence
Digital twining
Author(s) Name:  Heba Askr, Enas Elgeldawi, Heba Aboul Ella, Yaseen A. M. M. Elshaier, Mamdouh M. Gomaa & Aboul Ella Hassanien
Journal name:  Artificial Intelligence Review
Conferrence name:  
Publisher name:  Springer
DOI:  10.1007/s10462-022-10306-1
Volume Information:  
Paper Link:   https://link.springer.com/article/10.1007/s10462-022-10306-1