Research Area: Machine Learning
Seizure prediction can increase independence and allow preventative treatment for patients with epilepsy. We present a proof-of-concept for a seizure prediction system that is accurate, fully automated, patient-specific, and tunable to an individual-s needs.Intracranial electroencephalography (iEEG) data of ten patients obtained from a seizure advisory system were analyzed as part of a pseudoprospective seizure prediction study. First, a deep learning classifier was trained to distinguish between preictal and interictal signals. Second, classifier performance was tested on held-out iEEG data from all patients and benchmarked against the performance of a random predictor. Third, the prediction system was tuned so sensitivity or time in warning could be prioritized by the patient. Finally, a demonstration of the feasibility of deployment of the prediction system onto an ultra-low power neuromorphic chip for autonomous operation on a wearable device is provided.The prediction system achieved mean sensitivity of 69% and mean time in warning of 27%, significantly surpassing an equivalent random predictor for all patients by 42%.This study demonstrates that deep learning in combination with neuromorphic hardware can provide the basis for a wearable, real-time, always-on, patient-specific seizure warning system with low power consumption and reliable long-term performance.
Keywords:
Epileptic Seizure Prediction
Big Data
Deep Learning
Intracranial electroencephalography (iEEG)
Author(s) Name: Isabell Kiral-Kornek, Subhrajit Roy , Ewan Nurse, Benjamin Mashford , Philippa Karoly, Thomas Carroll, Daniel Payne , Susmita Saha, Steven Baldassano , Terence O-Brien , David Grayden, Mark Cook, Dean Freestone, Stefan Harrer
Journal name: EBioMedicine
Conferrence name:
Publisher name: Elsevier
DOI: 10.1016/j.ebiom.2017.11.032
Volume Information: Volume 27, January 2018, Pages 103-111
