Research Area:  Machine Learning

Abstract:

Artificial intelligence tools are gaining more and more ground each year in bioinformatics. Learning algorithms can be taught for specific tasks by using the existing enormous biological databases, and the resulting models can be used for the high-quality classification of novel, un-categorized data in numerous areas, including biological sequence analysis. Here, we introduce SECLAF, a webserver that uses deep neural networks for hierarchical biological sequence classification. By applying SECLAF for residue-sequences, we have reported [Methods (2018), https://doi.org/10.1016/j.ymeth.2017.06.034] the most accurate multi-label protein classifier to date (UniProt—into 698 classes—AUC 99.99%; Gene Ontology—into 983 classes—AUC 99.45%). Our framework SECLAF can be applied for other sequence classification tasks, as we describe in the present contribution.

Keywords:  
Webserver
Deep Neural Network
Hierarchical
Biological
Sequence Classification
Machine Learning
Deep Learning

Author(s) Name:  Balázs Szalkai, Vince Grolmusz

Publisher name:  Oxford University Press

DOI:  10.1093/bioinformatics/bty116

Volume Information:  Volume 34, Issue 14, 15 July 2018, Pages 2487–2489

Paper Link:   https://academic.oup.com/bioinformatics/article/34/14/2487/4911884?login=false