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Structural Bioinformatics and Deep Learning of Metalloproteins: Recent Advances and Applications - 2022

Structural Bioinformatics And Deep Learning Of Metalloproteins: Recent Advances And Applications

Research Paper on Structural Bioinformatics And Deep Learning Of Metalloproteins: Recent Advances And Applications

Research Area:  Machine Learning

Abstract:

All living organisms require metal ions for their energy production and metabolic and biosynthetic processes. Within cells, the metal ions involved in the formation of adducts interact with metabolites and macromolecules (proteins and nucleic acids). The proteins that require binding to one or more metal ions in order to be able to carry out their physiological function are called metalloproteins. About one third of all protein structures in the Protein Data Bank involve metalloproteins. Over the past few years there has been tremendous progress in the number of computational tools and techniques making use of 3D structural information to support the investigation of metalloproteins. This trend has been boosted by the successful applications of neural networks and machine/deep learning approaches in molecular and structural biology at large. In this review, we discuss recent advances in the development and availability of resources dealing with metalloproteins from a structure-based perspective. We start by addressing tools for the prediction of metal-binding sites (MBSs) using structural information on apo-proteins. Then, we provide an overview of the methods for and lessons learned from the structural comparison of MBSs in a fold-independent manner. We then move to describing databases of metalloprotein/MBS structures. Finally, we summarizing recent ML/DL applications enhancing the functional interpretation of metalloprotein structures.

Keywords:  
Structural Bioinformatics
Deep Learning
Metalloproteins
Machine Learning

Author(s) Name:  Claudia Andreini and Antonio Rosato

Journal name:  IJMS

Conferrence name:  

Publisher name:  MDPI

DOI:  10.3390/ijms23147684

Volume Information:  Volume 23, Issue 14